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Managing Post-Op Pain at Home: Medicines

Pain after an operation (post-op pain) is common and expected. These guidelines can help you stay as comfortable as possible.

Taking pain medicines

  • Take only the medicines that your health care provider tells you to take.
  • Don't take more than prescribed. Don't take your next dose sooner than prescribed.
  • Take pain medicines with some food to prevent an upset stomach.
  • Don't drink alcohol while using pain medicines.
  • Don't drive while taking opioid pain medicines.

Types of pain medicines

Non-opioid

  • Check with your health care provider before you take any over-the-counter (OTC) pain reliever in addition to or instead of your prescribed pain medicine.
  • Non-opioids include OTC acetaminophen and ibuprofen and some prescription pain relievers.
  • All relieve mild to moderate pain. Some reduce swelling.
  • Possible side effects include stomach upset and bleeding. High doses may cause kidney or liver problems.

Opioid

  • Opioids are available only by prescription.
  • Opioids ease moderate to severe pain.
  • Possible side effects include stomach upset, nausea, drowsiness, rash, and itching.
  • Opioids may cause constipation. To help prevent this, eat high-fiber foods and drink plenty of water.
  • Your health care provider may recommend a stool softener.
  • Don't drive, make important decisions, or operate machinery while taking opioids.

When to call your doctor

Contact your health care provider or seek medical attention right away if you:

  • Have nausea, vomiting, diarrhea, constipation, or stomach cramps.
  • Have breathing problems or a fast, racing heart rate. (Call 911.)
  • Feel tired, sluggish, or dizzy.
  • Have a skin rash or other allergic symptoms.
  • Have pain that is not eased with the pain medicine.
Online Medical Reviewer: Jonas DeMuro MD
Online Medical Reviewer: Raymond Turley Jr PA-C
Online Medical Reviewer: Rita Sather RN
Date Last Reviewed: 2/1/2025
© 2000-2026 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
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